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ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 3  |  Page : 169-173

The expression of pulpal substance P after dentinal application of Escherichia coli lipopolysaccharide


1 Department of Conservative Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
2 Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
3 Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
4 Department of Forensic Odontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
5 Resident of Conservative Dentistry Specialist Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Dr. Kun Ismiyatin
Department of Conservative Dentistry, Faculty of Dental Medicine, Campus A Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No. 47, Surabaya 60132
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sej.sej_92_18

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Purpose: The purpose of the research was to quantify the expressions of substance P (SP) in sensory nerve cells contained in the dental pulp of Wistar rats following the application of Escherichia coli lipopolysaccharide (LPS). Materials and Methods: Forty-two male Wistar rats were divided into six groups (n = 7): Groups C1 and C2 received no treatment and served as negative controls; Groups C3 and C4 only had cavity preparation; and Groups T1 and T2 received cavity preparation and treated with LPS. All teeth were subjected to immunohistochemistry analysis of SP expression at 24 h (C1, C3, and T1) and at 72 h (C2, C4, and T2). Results: There was a significant increase in the SP of the T1 group compared to the C1 and C3 groups and of the T2 group compared to the C2 and C4 groups. While there was no significant difference in the expression of SP between the C1 and C2 groups, a significant increase was found in T1 group compared to that of the T2 group and in the C3 group compared to the C4 group (P < 0.05). Conclusion: The application of LPS to teeth resulted in the highest expression of SP after 24 h which then decreased after 72 h.


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